Label-free Raman spectroscopy provides early determination and precise localization of breast cancer-colonized bone alterations† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc02905e

1Department of Mechanical Engineering, Johns Hopkins University, Baltimore, MD, USA. 2Division of Cancer Imaging Research, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA. 3Indiana University School of Medicine, Indianapolis, IN, USA. 4Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA. 5Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.